Neuroscience Program

Juan Raul Cebral

Juan Raul Cebral

Juan Raul Cebral

Associate Professor, Center for Computational Fluid Dynamics, Deparment of BioEngineering

Patient-specific computational fluid dynamics modeling of blood flows in cerebral arteries and aneurysms; understanding the role of hemodynamics in the mechanisms responsible for aneurysm initiation, growth and rupture; risk assessment; and medical device modeling (flow diverters).

Juan R. Cebral is a Professor at the Bioengineering Department, Volgenau School of Engineering, and a member of the Center for Computational Fluid Dynamics at George Mason University, in Fairfax, Virginia, USA. He finished his undergraduate studies in Physics at the University of Buenos Aires, Argentina in 1991 and received his PhD in Computational Sciences and Informatics from George Mason University in 1996. He conducts research on image-based computational modeling of cerebral blood flow and aneurysms in close collaboration with clinicians from Inova Fairfax Hospital. He has co-authored over 100 journal papers, 10 book chapters, and over 200 conference papers. His research has been funded by the National Institutes of Health, the American Heart Association, the Whitaker Foundation as well as industrial partners such as Philips Healthcare and Boston Scientific.

Current Research

We are collaborating with Dr. Anne Robertson from the University of Pittsburgh and Dr. Khaled Aziz from Allegheny General Hospital on a project that aims at connecting aneurysm hemodynamics to the structure and mechanical properties of the aneurysm wall, using a combination of image-based computational modeling, multi-photon microscopy imaging of human aneurysm tissue harvested during surgery, and mechanical testing. This work is supported by the NIH through an R21 grant.

We are collaborating with Dr. David Kallmes and Dr. Ramanathan Kadirvel from the Mayo Clinic on a project that studies the relationship between the blood flow dynamics and the thrombosis and tissue growth in cerebral aneurysms treated with flow diverting devices. In this project we use a combination of multi-modality imaging, image-based computational modeling, and histology analysis of experimental aneurysms created in rabbits.

 

Selected Publications

Chung BJ, Doddasomayajula R, Mut F, Detmer F, Pritz M, Hamzei-Sichani F, Brijikjiki W, Kallmes D, Jimenez C, Putman C, Cebral JR, “Angio-architectures and hemodynamics characteristics of posterior communicating artery aneurysms and their association with rupture status”, AJNR Am J Neuroradiol 2017 – in press

Doddasomayajula R, Chung BJ, Hamzei-Sichani F, Putman CM, Cebral JR, “Differences in hemodynamics and rupture rate of aneurysms at the bifurcation of the basilar and internal carotid arteries”, AJNR Am J Neuroradiol 2017 (DOI: 10.3174/ajnr.A5088) – in press.

Cebral JR, Ollikainen E, Chung BJ, Mut F, Sippola V, Jahromi BR, Tulamo R, Hernesniemi J, Niemela M, Robertson A, Frosen J, “Flow conditions in intracranial aneurysm lumen associate with inflammation and degenerative changes of the aneurysm wall”, AJNR 38(1): 119-126, 2017 (DOI: 10.3174/ajnr.A4951).

Cebral JR, Duan X, Gade PS, Chung BJ, Mut F, Aziz K, Robertson AM, “Regional mapping of flow and wall characteristics of intracranial aneurysms”, ABME, 44(12): 3553-3567, 2016 (DOI: 10.1007/s10439-016-1682-7).

Cebral JR, Duan X, Chung BJ, Putman CM, Aziz K, Robertson A, “Wall mechanical properties and hemodynamics of unruptured intracranial aneurysms”, AJNR 36(9): 1695-1703, 2015 (DOI: 10.3174/ajnr.A4358). 

Robertson A, Duan X, Aziz K, Hill M, Watkins S, Cebral JR, “Diversity in the strength and structure of unruptured cerebral aneurysms”, ABME 43(7): 1502-1515, 2015 (DOI 10.1007/s10439-015-1252-4).

Expanded Publication List

Doddasomayajula R, Chung BJ, Mut F, Jimenez C, Hamzei-Sichani F, Putman C, Cebral JR, “Hemodynamic characteristics of ruptured and unruptured multiple aneurysms at mirror and ipsilateral locations”, AJNR – in review.

Chung BJ, Doddasomayajula R, Mut F, Detmer F, Pritz M, Hamzei-Sichani F, Brijikjiki W, Kallmes D, Jimenez C, Putman C, Cebral JR, “Angio-architectures and hemodynamics characteristics of posterior communicating artery aneurysms and their association with rupture status”, AJNR 2017 – in press

Cebral JR, Mut F, Chung BJ, Spelle L, Moret J, van Nijnatten F, Ruijters D, “Understanding angiography-based aneurysm flow fields through comparison to computational fluid dynamics”, AJNR 2017, accepted

Doddasomayajula R, Chung BJ, Hamzei-Sichani F, Putman CM, Cebral JR, “Differences in hemodynamics and rupture rate of aneurysms at the bifurcation of the basilar and internal carotid arteries”, AJNR 2017 (DOI: 10.3174/ajnr.A5088) – in press.

Khan AA, Sikdar S, Hatsukami T, Cebral JR, Jones M, Huston J, Howard G, Lal BK, “Noninvasive characterization of carotid plaque strain”, J. Vasc. Surg., 65(6): 1653-1663, 2017 (DOI: 10.1016/j.jvs.2016.12.105).

Cebral JR, Ollikainen E, Chung BJ, Mut F, Sippola V, Jahromi BR, Tulamo R, Hernesniemi J, Niemela M, Robertson A, Frosen J, “Flow conditions in intracranial aneurysm lumen associate with inflammation and degenerative changes of the aneurysm wall”, AJNR 38(1): 119-126, 2017 (DOI: 10.3174/ajnr.A4951).

Salvador-Morales C, Brahmbhatt B, Marques-Miranda V, Aryan-Duran I, Canan J, Gonzalez-Nilo F, Vilos C, Cebral JR, Mut F, Lohner R, Leong B, Sundaresan G, Zweit J, “Mechanistic studies of the self-assembly of PLGA patchy particles and their potential applications in biomedical imaging”, Langmuir, 32(31): 7929-42, 2016 (DOI: 10.1021/acs.;angmuir.6b02177).

Cebral JR, Duan X, Gade PS, Chung BJ, Mut F, Aziz K, Robertson AM, “Regional mapping of flow and wall characteristics of intracranial aneurysms”, ABME, 44(12): 3553-3567, 2016 (DOI: 10.1007/s10439-016-1682-7).

Rouchaud A, Ramana C, Brinjikji W, Ding YH, Dai D, Gunderson T, Cebral JR, Kallmes D, Kadirvel R, “Wall apposition is a key factor for aneurysm occlusion after flow diversion: a histological evaluation in 41 rabbits”, AJNR 2016 (DOI: 10.3174/ajnr.A4848) – in press.

Brinjikji W, Chung BJ, Jimenez C, Putman CM, Kallmes DF, Cebral JR, “Hemodynamics differences between unstable and stable unruptured aneurysms independent of size and location: pilot study”, JNIS 2016 (DOI: 10.1136/neurointsurg-2016-012327) – in press.

Theielen E, McClure M, Rouchaud A, Ding YH, Dai D, Schroeder D, Cebral JR, Kallmes D, Kadirvel R, “Concomitant coiling reduces metalloproteinases levels in flow diverter-treated aneurysms but anti-inflammatory treatment with cyclosporine has no effect”, JNIS, 9(3), 307-310, 2016 (DOI: 10.1136/neurintsurg-2015-012207).

Rouchaud A, Johnson C, Theielen E, Ding YH, Schroeder D, Dai D, Brinjikji W, Cebral JR, Kallmes D, Kadirvel R, “Differential gene expression in coiled versus flow diverter-treated aneurysms: a RNA sequencing analysis in rabbit aneurysms model”. AJNR, 37(6): 1114-21, 2016 (DOI: 10.3174/ajnr.A4648).

Rasheed N, Khorasani A, Cebral JR, Mut F, Lohner R, Salvador Morales C, “Mechanisms involved in the formation of biocompatible lipid polymeric hollod patchy particles”, Langmuir Journal, 31(24): 6639-6648, 2015.

Cebral JR, Duan X, Chung BJ, Putman CM, Aziz K, Robertson A, “Wall mechanical properties and hemodynamics of unruptured intracranial aneurysms”, AJNR 36(9): 1695-1703, 2015 (DOI: 10.3174/ajnr.A4358). [nominated for 2015 best AJNR paper]

Berg P, Roloff C, Beuing O, Sugiyama SI, Aristokleus N, Anayiotos A, Ashton N, Bressloff N, Brown A, Chung BJ, Cebral JR, Copelli G, Fu W, Qiao A, Geers A, Hodis S, Dragomir-Daescu D, Imdieke E, Khan M, Valen-Sendstad, Kono K, Meng H, Xiang J, Menon P, Albal P, Mierka O, Munster R, Morales H, Osman J, Goubergrits L, Pallares J, Cito S, Passalacqua A, Piskin S, Pekkan K, Ramalho S, Marques N, Sanchi S, Schumacher K, Sturgeon J, Svihlova H, Hron J, Usera G, Mendina M, Steinman D, Janiga G, “The Computational Fluid Dynamics Rupture Challenge 2013 – Phase II: Variability of hemodynamic simulations in two intracranial aneurysms”, J Biomech Eng, 137(12): 121008 (DOI: 10.1115/1.4031794) 2015.

Robertson A, Duan X, Aziz K, Hill M, Watkins S, Cebral JR, “Diversity in the strength and structure of unruptured cerebral aneurysms”, ABME 43(7): 1502-1515, 2015 (DOI 10.1007/s10439-015-1252-4).

Hodis S, Ding YH, Dai D, Lingineni R, Mut F, Cebral JR, Kallmes D, Kadirvel R, “Relationship between aneurysm occlusion and flow diverting device oversizing in a rabbit model”, JNIS 8(1): 94-98, 2016 (DOI: 10.1136/neuintsurg-2014-011487).

Sforza D, Kono K, Tateshima S, Vinuela F, Putman CM, Cebral JR, “Hemodynamics in growing and stable cerebral aneurysms”, JNIS, 8(4): 407-412, 2016 (DOI: 10.1136/neurointsurg-2014-011339)

Puffer C, Dai D, Ding YH, Cebral JR, Kallmes D, Kadirvel R, “Gene expression comparison of flow diversion and coiling in an experimental aneurysm model”, J NeuroInterv Surg 7(12): 926-930, 2015 (DOI: 10.1136/neurintsurg-2014-011452).

Chung B, Mut F, Kadirvel R, Lingineni R, Kallmes D, Cebral JR, “Hemodynamic analisys of fast and slow occlusions by flow diversion in rabbit models”, J NeuroInterv Surg 7(12): 931-935, 2015 (DOI: 10.1136/neurointsurg-2014-011412).

Castro MA, Ahumada Olivares MC, Putman CM, Cebral JR, “Unsteady wall shear stress analysis from image-based computational fluid dynamic aneurysm modes under Newtonian and Casson rheological models”, Med Biol Eng Comput, 52(10): 827-839, 2014 (DOI 10.1007/s11517-014-1189-z)

Chung B, Cebral JR, “CFD for evaluation and treatment planning of aneurysms: review of proposed clinical uses and their challenges”, Ann Biomed Eng, 43(1): 122-138, 2015 (DOI 10.1007/s10439-014-1093-6)

Cebral JR, Vazquez M, Sforza DM, Houzeaux G, Tateshima S, Scrivano E, Bleise C, Lylyk P, Putman CM, “Analysis of hemodynamics and wall mechanics at sites of cerebral aneurysm rupture”, J NeuroIntervent Surg, 7: 530-536, 2015 (DOI 10.1136/neurintsurg-2014-011247)

Mut F, Raschi M, Scrivano E, Bleise C, Chudyk J, Ceratto R, Lylyk P, Cebral JR, “Association between hemodynamic conditions and occlusion times after flow diversion in cerebral aneurysms”, JNIS, 7(4), 286-290, 2015 (DOI: 10.1136/neurintsurg-2013-011080) [images in cover]

Cebral JR, Mut F, Raschi M, Hodis S, Ding YH, Erickson BJ, Kadirvel R, Kallmes D, “Analysis of hemodynamics and aneurysm occlusion after flow diverting treatment in rabbit models”, AJNR 35(8): 1567-1573, 2014 – (DOI: 10.3174/ajnr.A3913).

Cebral JR, Raschi M, Mut F, Ding YH, Dai D, Kadirvel R, Kallmes D, “Analysis of flow changes in side branches jailed by flow diverters”, IJNBME, 30(10): 988-999, 2014 (DOI: 10.1002/cnm.2640).

Cebral JR, Mut F, Raschi M, Ding YH, Kadirvel R, Kallmes D, “Strategy for analysis of flow diverting devices based on multi-modality image-based modeling”, IJNMBE, 30(10), 951-968, 2014 (DOI: 10.1002/cnm.2638)

Byrne G, Gilmore R, Cebral JR, “Connecting curves in higher dimensions”, J. Phys. A: Math. Theor., 47: 215101, 2014 (DOI: 10.1088/1751-8113/47/21/215101)

Byrne G, Mut F, Cebral JR, “Vortex dynamics in intracranial aneurysms”, Journal of Applied Mathematics, arXiv: 1309.7875 [nlin.PS], 2013.

Raschi M, Mut F, Lohner R, Cebral JR, “Strategy for modeling flow diverters in cerebral aneurysms with porous medium”, IJNMBE, 30(9): 909-925, 2014 (DOI: 10.1002/cnm.2635).

Mut F, Wright S, Ascoli GA, Cebral JR, “Morphometric, geographic and territorial characterization of brain arterial trees”, IJNMBE, 30(7): 755-766, 2014 (DOI 10.1002/cnm.2627).

Mut F, Scrivano E, Bleise C, Lylyk P, Cebral JR, “Hemodynamics in two tandem aneurysms treated with flow diverters”, IJNMBE 30(4): 517-524, 2014 (DOI 10.1002/cnm.2614).

Byrne G, Mut F, Cebral JR, “Quantifying the large-scale hemodynamics of intracranial aneurysms”, American Journal of Neuroradiology, 35(2): 333-338, 2014 (DOI 10.3174/ajnr.A3678)

Mut F, Ruijters D, Babic D, Bleise C, Lylyk P, Cebral JR, “Effects of changing physiologic conditions on the in vivo quantification of hemodynamic variables in cerebral aneurysms treated with flow diverting devices”, IJNMBE, 30(1): 135-142, 2014.

Wright S, Kochunov P, Mut F, Bergamino M, Brown K, Mazziotta J, Toga A, Cebral JR, Ascoli G, “Digital reconstruction and morphometric analysis of human brain arterial vasculature from magnetic resonance angiography”, NeuroImage, 82: 170-181, 2013.

Cebral JR, Raschi M, “Suggested connections between risk factors of intracranial aneurysms: a review”, Annals of Biomedical Engineering, 41(7): 1366-1383, 2013 (DOI: 10.1007/s10439-012-0723-0)

Mut F, Cebral JR, “Effects of flow diverting device oversizing on hemodynamics alteration in cerebral aneurysms” AJNR 33(10):2010-2016, 2012 (DOI: 10.3174/ajnr.A3080).

Cebral JR, Meng H, “Counterpoint: Realizing the Clinical Utility of Computational Fluid Dynamics – Closing the Gap”, AJNR 33(3): 396-398, 2012 (DOI: 10.3147/ajnr.A2994)

Sforza D, Putman CM, Cebral JR, “Computational Fluid Dynamics (CFD) in Brain Aneurysms”, IJNMBE, 28 (6-7): 801-808, 2012 (DOI: 10.1002/cnm.1481).

Sforza D, Putman CM, Tateshima S, Viñuela F, Cebral JR, “Effects of peri-aneurysmal environment during the growth of cerebral aneurysms: a case study”, AJNR, 33:115-120, 2012 (DOI: 10.3147/ajnr.A2908)

Raschi M, Mut F, Byrne G, Putman CM, Tateshima S, Viñuela F, Tanoue T, Tanishita K, Cebral JR, “CFD and PIV analysis of hemodynamics in a growing intracranial aneurysm”, IJNMBE, 28(2): 214-228, 2012 (DOI: 10.1002/cnm.1459, 2011)

Cebral JR, Mut F, Weir J, Putman CM, “Quantitative characterization of the hemodynamic environment in ruptured and unruptured brain aneurysms”, AJNR: 32(1), 145-152, 2011 (DOI 10.3174/ajnr.A2419)

Mut F, Löhner R, Chien A, Tateshima S, Viñuela F, Putman CM, Cebral JR, “Computational hemodynamics framework for the analysis of cerebral aneurysms”, IJNMBE 27(6): 822-839, 2011 (DOI 10.1002/cnm.1424) (PMCID: PMC3106350, NIHMSID: NIHMS252678)

Cebral JR, Mut F, Weir J, Putman CM, “Association of hemodynamic characteristics and cerebral aneurysm rupture”, AJNR, 32(2): 264-270, 2011 (DOI 10.3174/ajnr.A2274).

Cebral JR, Mut F, Raschi M, Scrivano E, Lylyk P, Putman CM, “Aneurysm rupture following treatment with flow diverting stents: computational hemodynamics analysis of treatment”, AJNR: 32(1), 27-33, 2011 (DOI 10.3174/ajnr.A2398)

Cebral JR, Mut F, Sforza D, Löhner R, Scrivano E, Lylyk P, Putman CM, “Clinical application of image-based CFD for cerebral aneurysms”, IJNMBE, 27(7): 977-992, 2011 (DOI: 10.1002/cnm.1373, 2010).

Tateshima S,Chien A, Sayre J, Cebral J, Viñuela F, “The effect of aneurysm geometry on the intra-aneurysmal flow condition”, Neuroradiology, 52(12): 1135-1141, 2010.

Oubel E, DeCraene M, Cebral JR, Blasco J, Macho J, Putman CM, Blanc R, Frangi A, “Wall motion estimation in intracranial aneurysms”, Phys. Meas. 31, 1119-1135, 2010.

Sforza D, Löhner R, Putman C, Cebral J, “Hemodynamic analysis of intracranial aneurysms with moving parent arteries: basilar tip aneurysms”, IJNMBE, 26(10): 1219-1227, 2010 (DOI: 10.1002/cnm.1385).

Sforza D, Putman CM, Scrivano E, Lylyk P, Cebral JR, “Blood flow characteristics in a terminal basilar tip aneurysm prior to its fatal rupture”, AJNR, 31:1127-1131, 2010 (DOI: 10.3147/ajnrA2021).

Mut F, Aubry R, Löhner R, Cebral JR, “Fast numerical solutions in patient-specific simulations of arterial models”, IJNMBE 26(1): 73-85, (DOI 10.1002/cnm.1235), 2010.

Cebral JR, Sheridan M, Putman CM, “Hemodynamics and bleb formation in intracranial aneurysms”, AJNR (10.3174/ajnr.A1819, October 1, 2009), 31(2): 304-310, 2010.

Cebral JR, “Progress in CFD for Bioengineering Modeling”, Int J CFD, 23(8): 567-568, 2009.

Castro M, Putman C, Radaelli A, Frangi A, Cebral JR, “Hemodynamics and rupture of terminal cerebral aneurysms”, Acad Radiol, 16(10): 1201-1207, 2009 .

Cebral JR, Putman CM, Alley M, Hope T, Bammer R, Calamante F, “Hemodynamics in Normal Cerebral arteries: qualitative comparison of 4D phase-contrast magnetic resonance and image-based computational fluid dynamics”, J. Eng. Math, Special Issue on Mathematical Modeling in Health and Medicine, 64(4): 367-378, 2009.

Appanaboyina S, Mut F, Löhner R, Putman CM, Cebral JR, “Simulation of intracranial aneurysm stenting: techniques and challenges”, CMAME 198 (45-46): 3567-3582, 2009 (DOI 10.1016/j.cma.2009.01.017).

Chien A, Castro MA, Tateshima S, Sayre J, Cebral J, Viñuela F, “Quantitative hemodynamic analysis of brain aneurysms at different locations”, AJNR 30(8): 1507-1512, 2009 (DOI: ajnr.A1600v1-0).

Chien A, Tateshima S, Sayre J, Castro M, Cebral JR, Viñuela F, “Patient-specific hemodynamic analysis of small internal carotid artery-ophthalmic artery aneurysms”, Surg Neurol (PMID: 19329152), 2009.

Castro MA, Putman CM, Sheridan M, Cebral JR, “Hemodynamic patterns of anterior communicating artery aneurysms: a possible association with rupture”, AJNR 30(2): 297-302 (PMID: 19131411), 2009.

Cebral JR, Hendrickson S, Putman CM, “Hemodynamics in a lethal basilar artery aneurysm just before its rupture”, AJNR 30: 95-98, (PMID: 18818279), 2009.

Appanaboyina S, Mut F, Löhner R, Scrivano E, Miranda C, Lylyk P, Putman CM, Cebral JR, “Computational modeling of blood flow in side arterial branches after stenting of intracranial aneurysms”, Int J CFD, 22(10), 669-676, 2008.

Chien A, Tateshima S, Castro M, Sayre J, Cebral JR, Viñuela F, “Patient-specific flow analysis of brain aneurysms at a single location: comparison of hemodynamic characteristics in small aneurysms”, Med Biol Eng Comput 46(11): 1113-1120, 2008.

Radaelli AG, Ausburger L, Cebral JR, Ohta M, Rüfenacht DA, Balossino R, Benndorf G, Hose DR, Marzo A, Metcalfe R, Mortier P, Mut F, Reymond P, Socci L, Verhegghe B, Frangi AF, “Reproducibility of haemodynamical simulations in a subject-specific stented aneurysm model – A report on the Virtual Intracranial Stenting Challenge 2007”, J. Biomech., 41(10): 2069-2081, 2008.

Cebral JR, Castro MA, Putman CM, Alperin N, “Flow-area relationship in internal carotid and vertebral arteries”, Physiol. Meas. 29: 585-594, 2008.

Löhner R, Cebral JR, Camelli F, Appanaboyina S, Baum JD, Mestreau EL, Soto O, “Adaptive embedded and immersed unstructured grid techniques”, Comp Meth Appl Mech Eng 197: 2173-2197, 2008.

Appanaboyina S, Mut F, Löhner R, Putman CM, Cebral JR, “Computational Fluid Dynamics of Stented Intracranial Aneurysms using Adaptive Embedded Unstructured Grids”, Int. J. Num. Methods Fluids, 57(5): 475-493, 2008.

Aubry R, Mut F, Löhner R, Cebral JR, “Deflated preconditioned conjugate gradient solvers for the pressure-Poisson equation”, J Comp Phys, 227(24):10196-10208, 2008.

Löhner R, Appanaboyina S, Cebral JR, “Parabolic Recovery of Boundary Gradients”, Comm Num Meth Eng, 24(12), 1611-1615, 2008 (DOI: 10.1002/cnm.1054).

Löhner R, Appanaboyina S, Cebral JR, “Comparison of Body-Fitted, Embedded and Immersed Solutions of Low Reynolds-Number 3-D Incompressible Flows”, Int J Num Methods Fluids, 57(1): 13-30, 2008 (DOI: 10.1002/fld.1604).

Cebral JR, Pergolizzi R, Putman CM, “Computational Fluid Dynamics Modeling of Intracranial Aneurysms: Qualitative Comparison with Conventional Angiography”, Acad Radiol, 14(7): 804-813, 2007.

Löhner R, Cebral JR, Camelli F, Appanaboyina S, Baum J, Mestreau E, Soto O, “Addaptive Embedded and Immersed Unstructured Grid Techniques”, Arch Comput Methods Eng, 14:279-301, 2007.

Millan D, Dempere-Marco L, Pozo JM, Cebral JR, Frangi A, “Morphological Characterization of Intracranial Aneurysms by Using 3D Moment Invatiants”, IEEE Trans Med Imaging, 26(9): 1270-1282, 2007.

Wood BJ, Locklin JK, Viswanathan A, Kruecker J, Haemerich D, Cebral JR, Sofer A, Cheng R, McCreedy E, Cleary K, McAuliffe M, Glossop N, Yanoff J, “Technologies for Guidance of Radiofrequency Ablation in the Multimodality Interventional Suite of the Future”, J Vasc Interv Radiol 18: 9-24, 2007.

Fyte-Krishner BS, Shawn B, Yim PJ, Cebral JR, Foran DJ, “Plaque morphology in high versus low shear stress regions of human carotid stenosis”, FASEB Journal, 21(5), A16, 2007.

Castro MA, Putman CM, Cebral JR, “Patient-Specific Computational Fluid Dynamics Modeling of Anterior Communicating Artery Aneurysms: A Study of the Sensitivity of Intra-Aneurysmal Flow Patterns to Flow Conditions in the Carotid Arteries”, AJNR , 27: 2061-2068, 2006.

Castro, M.A., C.M. Putman, and J.R. Cebral, “Computational fluid dynamics modeling of intracranial aneurysms: effects of parent artery segmentation on intra-aneurysmal hemodynamcis”. AJNR, 27: 1703-1709, 2006.

Castro MA, Putman CM, Cebral JR, “Patient-Specific Computational Modeling of Cerebral Aneurysms with Multiple Avenues of Flow from 3D Rotational Angiography Images”, Academic Radiology, 13(7): 811-821, 2006.

Löhner R, Yang C, Cebral JR, Camelli F, Soto O, Waltz J, “Improving the Speed and Accuracy of Projection-Type Incompressible Flow Solvers”, Comp Meth Appl Mech Eng, 195(23-24): 3087-3109, 2006.

Cebral JR, Castro MA, Burgess JE, Pergolizzi R, Putman CM, “Characterization of Cerebral Aneurysm for Assessing Risk of Rupture Using Patient-Specific Computational Hemodynamics Models” AJNR, 26: 2550-2559, 2005.

Cebral JR, Castro MA, Appanaboyina S, Putman CM, Millan D, Frangi A, “Efficient Pipeline for Image-Based Patient-Specific Analysis of Cerebral Aneurysm Hemodynamics: Technique and Sensitivity”, IEEE TMI 24(4): 457-467, special issue on vascular imaging, April 2005.

Cebral JR, Löhner R, “Efficient Simulation of Blood Flow Past Complex Endovascular Devices Using an Adaptive Embedding Technique”, IEEE TMI 24(4): 468-476, special issue on vascular imaging, April 2005.

Yim PJ, Cebral JR, Weaver A, Lutz R, Boudewijn G, Vasbinder C, Ho VB Choyke PL, “Estimation of Pressure Gradients at Renal Artery Stenoses”, MRM, 51: 969-977, 2004.

Cebral JR, Summers R, “Tracheal and Central Bronchial Aerodynamics Using Virtual Bronchoscopy and Computational Fluid Dynamics”, IEEE Trans. Medical Imaging, 23(8): 1021-1033, 2004.

Löhner R, Cebral JR, Yang C, Baum JD, Mestreau EL, Charman C, Pelessone D, “Large-scale fluid-structure interaction simulations”, Computing in Science and Engineering, 6(3): 27-37, 2004.

Soto O, Löhner R, Cebral JR, Camelli F, “A stabilized edge-based implicit incompressible flow formulation”, Comp. Methods Appl. Mech. Eng., 193: 2139-2154, 2004.

Cebral JR, Castro MA, Soto O, Löhner R, Alperin N, “Blood Flow Models of the Circle of Willis form Magnetic Resonance Data”, Journal of Engineering Math, 47(3-4): 369-386, 2003.

Löhner R, Cebral JR, Soto O, Yim PJ, Burgess JE, “Applications of Patient-Specific CFD in Medicine and Life Sciences”, Int. J. Numer. Meth. Fluids, 43: 637-650, 2003.

Calamante F, Yim PJ, Cebral JR, “Estimation of Bolus Dispersion Effects in Perfusion MRI Using Image-Based Computational Fluid Dynamics”, NeuroImage, 19: 341-353, 2003.

Cebral JR, Yim PJ, Löhner R, Soto O, Choyke PL, “Blood Flow Modeling in Carotid Arteries Using Computational Fluid Dynamics and Magnetic Resonance Imaging”, Academic Radiology, 9: 1286-1299, 2002.

Cebral JR, Camelli FE and Löhner R, “A Feature Preserving Volumetric Technique to Merge Surface Triangulations”, Int. J. Num. Methods Eng., 55:177-190, 2001.

Cebral JR, “Accurate Segmentation of Vessels from MRA Images”, Special Issue of International Journal of Bioelectromagnetism, Vol.3, No. 2, 2001.

Cebral JR, “Flow Predictions During Neuro-Surgery and Carotid Stenting”, Special Issue of International Journal of Bioelectromagnetism, Vol.3, No. 2, 2001.

Yim PJ, Cebral JR, Mullick R and Choyke PJ, “Vessel Surface Reconstruction with a Tubular Deformable Model”, IEEE Trans. Medical Imaging, 20(12), 1411-1421, 2001.

Cebral JR, Löhner R, Choyke PL and Yim PJ, “Merging of intersecting Triangulations for Finite Element Modeling”, J. Biomech., 34, 815-819, 2001.

Cebral JR and Löhner R, “From Medical Images to Anatomically Accurate Finite Element Grids”, Int. J. Num. Methdos Eng., 51, 985-1008, 2001.

Yim PJ, Cebral JR, Zhang Y, Lutz R, Choyke, PL “Evaluation of Magnetic Resonance Angiography for Measuring Arterial Wall Shear Stress”, Annals Biomed. Eng., vol. 28, supplement 1, p. S-59, 2000.

Löhner, R. and Cebral, J.R., “Generation of Non-Isotropic Unstructured Grids via Directional Enrichment”, Int. J. Num. Meth. Engng., 49, 219-232, 2000.

Cebral, J.R. and Löhner, R., “Conservative Load Projection and Tracking for Fluid-Structure Problems”, AIAA Journal, Vol. 35, No. 4, pp.687-692, 1997.

Grants and Fellowships

1. R155CA213093, National Institutes of Health

Role: Co-Inv. Funding: $436,572 Dates: 07/01/2017-06/30/2020 PI: Salvador-Morales (GMU)

Title: Engineering a novel theranostic device for breast cancer treatment based on multiplexing semiconducting patchy polymeric particles

The objective of this project is to optimize the production of patchy particles for imaging and treatment of cancer tumors using a combination of experimental and computational methods

 

2. R01NS097457, National Institutes of Health

Role: Co-Inv. Funding: $ 1,093,655.12 Dates:09/01/2016-08/31/2021 PI: Robertson (U.Pitt)

Title: Improving cerebral aneurysm risk assessment through understanding wall vulnerability and failure modes

The objective of this project is to connect flow conditions to wall structure and strength in cerebral aneurysms using resected tissue samples and computational modeling, and use this information to identify unruptured aneurysms at risk of rupture

 

3. R01NS076491, National Institutes of Health

Role:Co-PI Funding: $731,756.58 Dates:9/1/2016-8/31/2021 Co-PIs:Kardivel/Kallmes (Mayo)

Title: Computational and Biological Approach to Flow Diversion - Renewal

The major goal of this project is to model the hemodynamic alteration produced by flow diverting devices on animal models of cerebral aneurysms and relate them to long term aneurysm occlusion rates

 

4. Grant 222896, Jeffress Trust

Role: Co-Inv. Funding: $100,000 Dates: 06/30/16-06/29/2017 PI: Salvador-Morales

Title: Using comp. modeling for the design and optimization of novel cancer theranostics

The objective of this project is to optimize the production of patchy nanoparticles through improved understanding and control of the flow conditions created during the particle synthesis

 

5. R21 NS094780-02, National Institutes of Health

Role: PI Funding: $406,503 Dates: 09/15/2015-08/31/2018 PI: Cebral

Title: Improved evaluation of PCOM aneurysms: angio-architecture, hemodynamics & shape

The objective of this project is to identify angio-architecture and aneurysm characteristics that distinguish between ruptured and unruptured PCOM aneurysms and use this information to better assess rupture risk

 

6. Research Grant, Philips Health Care, The Netherlands

Role: PI Funding: $80,000 Dates: 08/01/2012-09/30/2016 PI: Cebral

Title: Evaluation of Flow Diversion Treatment for Cerebral Aneurysms

The overall objective of the project is to evaluate the prognostic value of average aneurysm flow velocity changes before and after treatment with flow diverting devices.

Courses Taught

ME 322 - Fluid Mechanics

BENG 304 - Modeling Physiologic Control Systems

BENG 499/590 - Biofluid Dynamics

CSI 701 - Foundations of Computational Sciences
CSI 702 - High Performance Computing
CSI 720 - Fluid Mechanics