Neuroscience Program

Robert Lipsky

Robert Lipsky

Robert Lipsky

Professor, External Faculty; INOVA

Molecular Neurogenetics

Dr. Robert Lipsky currently serves as the Director of Translational Research in the Department of Neurosciences at Inova Fairfax Hospital.  Since 2009, he has been an external faculty member with the rank of Professor in the Department of Molecular Neuroscience.  As part of an initiative to facilitate scientific research between George Mason University and Inova that directly impacts clinical practice, he founded and is head of the Inova-GMU Neuroscience Translational Research (INTR) Laboratory.  Prior to coming to Inova and George Mason, Robert Lipsky was an investigator at the NIH, where he was Chief of the Section on Molecular Genetics in the National Institute on Alcohol Abuse and Alcoholism.  Research in his laboratory centered on the molecular genetics of addiction and co-morbid disorders, such as major depression, and on defining molecular responses to brain injury, areas of work he still pursues in addition to research on epigenetic mechanisms (changes in DNA independent of nucleotide sequence) related to neuropsychiatric and neurodegenenerative disorders.  Robert Lipsky received his Ph.D. degree from Cornell University in genetics and biochemistry (1983).  He holds two U.S. patents in DNA sequence detection and has coauthored more than 100 peer-reviewed scientific publications. Robert Lipsky has served as a scientific advisor to the U.S. Army and for the NIH.  He is on the editorial board of several scientific journals.

Selected Publications

Hu XZ, Rush AJ, Charney D, Wilson AF, Sorant AJM, Panpanicoloaou GJ, Fava M, Trivedi MH, Wisniewski S, Laje G, Paddock S, McMahon FJ, Manji H, Lipsky RH. (2007). Association between a functional serotonin transporter promoter polymorphism and citalopram treatment in adult outpatients with major depression. Arch. Gen. Psych. 64:783-792.

Paddock S, Laje G, Charney D, Rush AJ, Wilson AF, Sorant, AJ, Lipsky RH, Wisniewski SR, Manji H, McMahon FJ. (2007). Association of GRIK4 with outcome of antidepressant treatment in the STAR*D cohort. Am. J. Psychiatry. 164: 1181-1188.

Jiang X, Tian F, Du Y, Copeland NG, Jenkins NA, Tessarollo L, Wu X, Pan H, Xu K, Kenney H, Egan SE, Turley H, Harris AL, Marini AM, Lipsky RH. (2008). BHLHB2 controls Bdnf promoter 4 activity and neuronal excitability. J. Neurosci. 28:  1118-1130.

Zhou Z, Zhu G, Hariri AR, Enoch MA, Scott D, Sinha R, Virkkunen M, Mash DC, Lipsky RH, Hu XZ, Hodgkinson CA, Xu K, Buzas B, Yuan Q, Shen PH, Ferrell RE, Manuck SB, Brown SM, Hauger RL, Stohler CS, Zubieta JK, Goldman D. (2008). Genetic variation in human NPY expression affects stress response and emotion. Nature. 452: 997-1001.

Roecklein KA, Rohan KJ, Duncan WC, Rollag MD, Rosenthal NE, Lipsky RH, Provencio I. (2009). A missense variant (P10L) of the melanopsin (OPN4) gene in seasonal affective disorder. J Affect Disord. 114: 279-285.

Tian F, Hu X-Z, Wu X, Jiang H, Pan H, Marini AM, Lipsky RH. (2009).  Dynamic chromatin remodeling events in hippocampal neurons are associated with NMDA receptor-mediated activation of Bdnf gene promoter 1. J Neurochem. 109: 1375-1388.

Blondeau N, Nguemeni C, Debruyne DN, Piens M, Wu X, Pan H, Hu X, Gandin C, Lipsky RH, Plumier J-C, Marini AM, Heurteaux C. (2009). Subchronic alpha-linolenic acid treatment enhances brain plasticity and exerts an antidepressant effect: A versatile potential therapy for stroke. Neuropsychopharmacology. 34: 2548-2559.

Krueger F, Pardini M, Huey ED, Raymont V, Solomon J, Lipsky R, Hodgkinson CA, Goldman D, Grafman J. (2011). The role of the met66 BDNF allele in the recovery of executive functioning following combat-related traumatic brain injury. J. Neurosci. 31:  598-606.

Martínez-Llordella M, Esensten JH, Bailey-Bucktrout SL, Lipsky RH, Marini A, Chen J, Mughal M, Mattson MP, Taub DD, Bluestone JA. (2013). CD28-inducible transcription factor DEC1 is required for efficient autoreactive CD4+ T cell response. J Exp Med. 210:1603-1619