Proteomic organization, evolution of signaling networks in neurons
Nadine Kabbani is a faculty member at the Krasnow Institute for Advanced Study and an Associate Professor in the Department of Molecular Neuroscience with a joint appointment in the School of Systems Biology. Her research focuses on the cellular and molecular mechanisms of nicotinic receptor drug actions in the brain and immune system. She is a member of the Society for Neuroscience, the Protein Society, the Society for Pharmacology and Experimental Therapeutics, and the VA Youth Tobacco Project. Dr. Kabbani serves on the editorial board for Amino Acids, Proteomics Insights, and the Children's Medical Safety Research Institute. She has been the recipient of awards from the National Institute for Neurological Disorders and Stroke, the Philip Morris Corporation, the Foundation for Medical Research, and the International Brain Research Organization. Her research is currently funded by the VA Foundation for Healthy Youth and the Wings for Life Spinal Cord Research Foundation. She is an author of 40+ published scientific articles and several book chapters. Dr. Kabbani pursued postdoctoral training in the laboratory of Professor Patricia Goldman-Rakic at Yale University and Professor Jean-Pierre Changeux at the Pasteur Institute. She received her doctorate in Pharmacology from the Pennsylvania State University School of Medicine.
The primary products of the genome are a vast array of proteins (the proteome) that codify the structure and function of cells throughout the body. This proteome represents a major post-genomic domain of organization in cells. Our research centers on identifying and characterizing protein interaction networks for the dopamine and nicotinic acetylcholine receptors in the adult and developing nervous system. An additional line of work explores the role of nicotinic receptor interacting proteins in immune cell function and T cell regulation.
Identification and characterization of a G protein-binding cluster in α7 nicotinic acetylcholine receptors. King JR, Nordman JC, Bridges SP, Lin MK, Kabbani N. J Biol Chem. 2015 Jun 18. [Epub ahead of print]
Microtubule dynamics at the growth cone are mediated by α7 nicotinic receptor activation of a Gαq and IP3 receptor pathway. Nordman JC, Kabbani N. FASEB J. 2014 Jul; 28(7): 2995-3006.
Axon targeting of the alpha 7 nicotinic receptor in developing hippocampal neurons by Gprin1 regulates growth. Nordman JC, Phillips WS, Kodama N, Clark SG, Del Negro CA, Kabbani N. J Neurochem. 2014 May; 129(4): 649-62.
The α4 nicotinic receptor promotes CD4+ T-cell proliferation and a helper T-cell immune response. Nordman JC, Muldoon P, Clark S, Damaj MI, Kabbani N. Mol Pharmacol. 2014 Jan; 85(1): 50-61.Are nicotinic acetylcholine receptors coupled to G proteins? N. Kabbani, J. C. Nordman, B. Corgiat, D.P. Veltri, A. Shehu, V. A. Seymour, D. J. Adams. BioEssays, 2013, in press.
Not so Cool? Menthol’s discovered actions on the nicotinic receptor and its implications for nicotine addiction. N. Kabbani. Front. Pharmacol. 23 July 2013 10.3389/fphar.2013.00095.
Menthol attenuates α7-nicotinic acetylcholine receptor function. A. Ashoor, J. C. Nordman,D. P. Veltri, K. S. Yang,L. Al Kury,Y. Shuba, M. Mahgoub, F. C. Howarth, C. Lupica, A. Shehu, N. Kabbani,M. Oz.. PLoS One, 23 Jul 2013 10.1371/journal.pone.0067674.
Capture of D2 dopamine receptor signaling complexes in striatal cells for mass spectrometry proteomic analysis. Kabbani N, Nordman JC. Methods Mol Biol. 2013, 964:43-60.
An interaction between α7 nicotinic receptors and a G-protein pathway complex regulates neurite growth in neural cells. Nordman J.C., Kabbani N.. J Cell Sci. 2012 Nov; 125(22): 5502-13.